The Endosafe®-PTS™ is a handheld spectrophotometer that utilizes FDA- licensed disposable cartridges for accurate, convenient endotoxin testing. With test. A multicenter comparison study between the Endosafe PTS rapid-release testing system and traditional methods for detecting endotoxin in cell-therapy products. The Endosafe®-PTS™ is a rapid, point-of-use test system that provides quantitative LAL results within 15 minutes. The PTS™ utilizes LAL reagents in an .

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The projects develop integrated lab-on-a-chip products in three areas related to space exploration: The device itself or reader weighs 2.

These three molecules are found mainly within gram-negative bacteriafungi and gram-positive bacteriarespectively. Endotoxin and glucan are detected with the Limulus amebocyte lysate LAL enzyme cascade, derived from the horseshoe crab Limulus polyphemus. By the amplification of a small signal, these enzyme cascades allow detection of very low amounts of starting microbial material.


An astronaut can take a swab sample endoswfe a cabin surface, dissolve it in endotoxin-free water, and analyze it quantitatively with LOCAD-PTS in microgravity, all in under 15 minutes. Traditional culture-based methods aboard the ISS take several days and often require return of samples to Earth for more in-depth analysis by scientists on the ground.

Endosafe-PTS Glucan Assay from Charles River – Product Description and Details

Endotoxin was found at every surface site where Colony Forming Units CFUs were endosafee with culture-based contact slide methods. Preliminary results with these cartridges showed similar patterns to those observed for endotoxin, but glucan was found at higher levels and found to be far more widespread throughout the ISS.

Tests with these cartridges have been performed during Expeditions 18 — Before LOCAD-PTS was launched to space, it was tested extensively in simulated microgravity with the use of parabolic flightto verify nominal function of the instrument and sample handling procedures. The goal of the experiment is to design and test procedures to monitor and document the spread of biological material associated with human spaceflight, both before and after launch, in preparation for the human exploration of the Moon and Mars.


This ‘swab’ was performed indirectly with the spacesuit gloves. From Wikipedia, the free encyclopedia. Karissa West performs microbial survey of Pad 39A August 7, Archived from the original on Gravitational Physiology, Volume 10, Issue 2, Retrieved from ” https: Archived copy as title Commons category link is on Endsafe.

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